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C. Apo C specific . Although both the LDL receptor and the LRP have been implicated in the uptake of chylomicron remnants, it has been difficult to determine which, if either, plays the dominant role in this process. Chylomicron remnants require four receptors for binding compared with one receptor per LDL particle [16], suggesting that with LDL receptor-deï¬ cient states, chylomicron remnant clearance may be more signiï¬ cantly compromised than LDL. Unlabeled chylomicron remnants did not reduce the binding of 125 I-asiaglycoprotein to plasma membranes, but did compete for 125 I-chylomicron remanant binding. During glyceryl trioleate absorption in the rat, mucosal triacylglycerol (TG) fatty acids have been shown to consist of only 71% exogenous oleate. Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. Both apolipoprotein E and lipoprotein lipase are constituents of chylomicron remnants, another triglyceride-rich lipoprotein which has been proposed as a physiological ligand for the VLDL receptor. due, at least in part, to a loss of receptors which can recognize chylomicron remnants. Characterization of chylomicron remnant binding to rat liver membranes. The role of the LDL receptor in clearance of LDL is well established. Receptors for chylomicron remnants are? Lipoprotein-receptor related protein (LRP) requires apoE to facilitates the binding of the sequestered remnants to this receptor. Previous. Cooper, A. D. Hepatic uptake of chylomicron remnants. THE low-density-lipoprotein (LDL) receptor is a cell-surface pro-tein that plays an important part in the metabolism of cholesterol by mediating the uptake of LDL from plasma into cells1. In rabbits, the VLDL receptor has been found predomi-nantly in heart, skeletal muscle, and adipose tissue, but not in the liver [14]. Chylomicron remnants are enriched with endogenous TG fatty acids, compared with their parent chylomicrons, which consist primarily of exogenous TG fatty acids. The two substances did not compete with each other for removal by the isolated perfused rat liver. [Google Scholar] Hui DY, Innerarity TL, Milne RW, Marcel YL, Mahley RW. "Chylomicron Remnants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Chylomicron remnants can then be taken up by hepatocytes via interaction with the LDL receptor which requires apoE. When the lipoprotein remnants contact them they become bound and sequester (confined) against the hepatic cell membrane. The metabolism of VLDL is very similar to that of chylomicrons, the major difference being that VLDL are assembled in hepatocytes to transport triglyceride containing fatty acids newly synthesized from excess glucose, or retrieved from the chylomicron remnants, to adipose tissue and muscle. The binding of chylomicron remnants was competitively inhibited in the presence of unlabeled remnants and to a lesser extent by unlabeled low-density lipoproteins. Moreover, colchicine and monensin which are endocytotic and lysozomal inhibitors, respectively, did not have any effect on the degradation of chylomicron remnants by macrophages from normal rabbits. Definition of chylomicron remnants in the Definitions.net dictionary. This latter process allows the remnant to be taken up via the chylomicron remnant receptor. chylomicron remnants is mediated at the surfaces ofparen- chymal liver cells by apolipoprotein B, E (LDL) receptors coded for by a single allelic pair of genes on chromosome 19 Impaired clearance of chylomicron remnants correlates with increased vascular disease risk in FH. Less clear the signifi- cance of the LDL receptor in clearance chylo- micron remnants. receptor is able to bind chylomicron remnants that are formed during the two-step pathway for chylomicron catabolism (1, 7). Because enterocytes have the apolipoprotein B-100/E receptor, this study was directed at determining whether the cells can take up and metabolize chylomicron remnants and, if so, whether this was receptor mediated. Information and translations of chylomicron remnants in the most comprehensive dictionary definitions resource on the web. Uptake . J Lipid Res. remnants moved from the cell surface to the perinu-clear regions over this period (data not shown). This article must therefore be hereby marked "advertise- In previous studies, chylomicron remnants or chylomicron remnant‐like particles (CRLPs) have been shown to induce extensive lipid accumulation in a variety of macrophage types, including the murine macrophage cell line J774 [], mouse peritoneal macrophages [], primary human monocyte‐derived macrophages [[3, 4]] and macrophages derived from the human monocyte cell line THP‐1 [[4, 5, 19, 20]]. A. Apo A specific . Chylomicron Remnants Chylomicrons Apolipoprotein B-48 Lipoproteins, VLDL Receptors, LDL Lipoproteins Vitamin A Triglycerides Lymph Apolipoproteins E Liver Low Density Lipoprotein Receptor-Related Protein-1 Fetuins Apolipoproteins Corn Oil Cholesterol Emulsions Lipase Apolipoproteins B Cholesterol Esters Gold Colloid Lipoprotein Lipase Receptors, Lipoprotein Lactoferrin alpha … The converse also was true. Science 264:1471–1474 CAS The loss of regulation of cholesterol synthesis by die- tary cholesterol (1) has been well documented in trans- plantable hepatomas (2), in primary hepatomas from several species including man (3,4) and in premalignant liver (5, 6). Keywords: chylomicron remnants; dietary fat; LDL recep- The publication costs of this article were defrayed in part by page charge payment. Chylomicron remnants were degraded by alveolar macrophages from Watanabe heritable hyperlipidemic (WHHL) rabbits, which are devoid of LDL receptor activity. The present studies of chylomicron metabolism were conducted in rabbits, since this species has been used extensively in lipoprotein studies. 1982 Jan; 23 (1):42–52. Next . APOB48 and APOE are important for the identification of chylomicron remnants in the liver due to endocytosis and degradation. chylomicron remnants might provide a useful means of detecting subtle changes in LDL receptor expression. What does chylomicron remnants mean? Both type 1 and type 2 diabetes increase the risk of atherosclerotic cardiovascular disease (CVD). The concentration of chylomicron remnants used for Meaning of chylomicron remnants. Moreover, a large number of people with prediabetes are at risk for developing frank diabetes worldwide. The liver is the primary organ responsible for the clearance of pro-atherogeniclipoproteins, which include intermediate-density and low-density lipoproteins (IDL and LDL, respectively) and chylomicron remnants. J. Lipid &S. 1997. Moreover, it is impractical to use proper amounts of the tracer, because its tracee, chylomicron remnants, is virtually absent in the plasma of fasted mice (1, 34). 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